The role of clinical studies for pets with naturally occurring tumors in translational cancer research : workshop summary / Sharyl J. Nass and Heather Gorby, rapporteurs ; National Cancer Policy Forum, Board on Health Care Services, Institute of Medicine.
Traditional preclinical mouse models of cancer have been very useful for studying the biology of cancer, however they often lack key characteristics of human cancers. As a result, many novel drug candidates fail in human clinical trials despite evidence of drug efficacy in those preclinical models....
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| Corporate Contributors: | , , |
| Format: | Electronic Conference Proceeding eBook |
| Language: | English |
| Published: |
Washington, DC :
The National Academies Press,
[2015]
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| Series: | Online access: NCBI NCBI Bookshelf.
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| Subjects: | |
| Genre/Form: | Congress proceedings (reports) Conference papers and proceedings. |
| Local Note: | ProQuest Ebook Central |
| Summary: | Traditional preclinical mouse models of cancer have been very useful for studying the biology of cancer, however they often lack key characteristics of human cancers. As a result, many novel drug candidates fail in human clinical trials despite evidence of drug efficacy in those preclinical models. Thus, researchers are seeking new approaches to augment preclinical knowledge before undertaking clinical trials for human patients. Recently, there has been renewed interest in comparative oncology - the study of naturally developing cancers in animals as models for human disease - as one way to improve cancer drug development and reduce attrition of investigational agents. Tumors that spontaneously develop in pet dogs and other companion animals as a result of normal aging share many characteristics with human cancers, such as histological appearance, tumor genetics, biological behavior, molecular targets, and therapeutic response. In June 2015 the Institute of Medicine hosted a workshop to examine the rationale and potential for integrating clinical trials for pet patients with naturally occurring cancers into translational cancer research and development. Participants discussed the research needs, strategies, and resources to support greater integration of clinical trials for pets with cancer into translational research pathways, and challenges and potential solutions for facilitating that integration. This report summarizes the presentations and discussions from the workshop. |
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| Item Description: | "The National Academies of Sciences, Engineering, Medicine." |
| Physical Description: | 1 online resource (1 PDF file (xx, 62 pages)) : illustrations |
| Bibliography: | Includes bibliographical references. |
| ISBN: | 9780309379915 0309379911 |
| Funding Information Note: | This project was supported by the Animal Cancer Foundation; the College of Veterinary Medicine at North Carolina State University; the Cornell University School of Veterinary Medicine; Flint Animal Cancer Center, Colorado State University; the Morris Animal Foundation; the Ohio State University School of Veterinary Medicine; Purdue University College of Veterinary Medicine and the Center for Cancer Research; the Skippy Frank Translational Medicine and Life Sciences Fund; the University of California, Davis, School of Veterinary Medicine; the University of Colorado Cancer Center; the University of Florida College of Veterinary Medicine; the University of Georgia College of Veterinary Medicine; the University of Illinois College of Veterinary Medicine; the University of Minnesota College of Veterinary Medicine; the University of Missouri College of Veterinary Medicine and the Ellis Fischel Cancer Center; the University of Pennsylvania; the University of Wisconsin-Madison Carbone Cancer Center, Institute for Clinical and Translational Research, and the School of Veterinary Medicine; and the Washington State University College of Veterinary Medicine. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project. |